The nature of gentamicin-induced neuromuscular block.

نویسنده

  • T Torda
چکیده

Gentamicin in concentrations of 0.05--0.2 mmol litre-1 blocked neuromuscular transmission in the toad sartorius nerve--muscle preparation by decreasing the release of transmitter. In concetnrations of 0.5--1 mmol litre-1 it decreased the amplitude of the miniature end-plate current by a curare-like action, without affecting the mean open channel lifetime.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Do bupivacaine, clindamycin, and gentamicin at their clinical concentrations enhance rocuronium-induced neuromuscular block?

BACKGROUND Bupivacaine, clindamycin, and gentamicin inhibit neuromuscular (NM) conduction. When they are combined, they may synergistically reduce the effective concentration of each to the therapeutic concentration in augmenting rocuronium-induced NM block. Thus, the aim of this study was to investigate whether combinations of the three drugs, at around their therapeutic concentrations, potent...

متن کامل

The effect of high concentration of magnesium with ropivacaine, gentamicin, rocuronium, and their combination on neuromuscular blockade

BACKGROUND Magnesium, ropivacaine, gentamicin, and rocuronium block neuromuscular (NM) transmission by different mechanisms. Therefore, concurrent administration of these agents may induce prolonged muscle paralysis via synergistic interaction. This study investigated the efficacy and safety of NM block caused by the administration of high concentrations of magnesium in combination with ropivac...

متن کامل

The synergistic effect of gentamicin and clindamycin on rocuronium-induced neuromuscular blockade

BACKGROUND Gentamicin reduces acetylcholine release and clindamycin causes end-plate ion channel blockade. Because of these reasons, two drugs show muscular relaxant effect and potentiate the action of nondepolarizing neuromuscular agents. This study was intended to evaluate the effect of gentamicin and clindamycin on rocuronium-induced neuromuscular blockade and the interaction between these d...

متن کامل

Antibiotics and muscle relaxation

Corresponding author: Jong-Man Kang, M.D., Ph.D., Department of Anesthesiology and Pain Medicine, Kyung Hee University Hospital at Gangdong, 149, Sangil-dong, Gangdong-gu, Seoul 134-090, Korea. Tel: 82-2-440-6193, Fax: 82-2-440-7808, E-mail: [email protected] This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creati...

متن کامل

Reno-protective effect of Rheum turkestanicum against gentamicin-induced nephrotoxicity

Objective(s): Gentamicin belongs to the family of aminoglycoside antibiotics and is a preferred drug in developing countries because of its low cost, availability, and potent effects against bacterial. However, gentamicin can induce nephrotoxicity. In this research, hydroalcoholic extract of Rheum turkestanicum was used against gentamicin- induced nephrotoxicity. Rheum turkestanicum is used aga...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • British journal of anaesthesia

دوره 52 3  شماره 

صفحات  -

تاریخ انتشار 1980